Scientific Director, Biotherapeutics Design & Optimization

Company: Hispanic Alliance for Career Enhancement
Location: Indianapolis
Posted on: May 3, 2025

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work worldwide to discover and bring life-changing medicines to those in need, improve disease understanding and management, and give back through philanthropy and volunteerism. We prioritize our work and put people first. We seek individuals committed to improving lives globally.
Organization Overview:
Lilly's Biotechnology Discovery Research (BioTDR) has a proven track record in discovering, optimizing, and delivering novel biotherapeutic medicines for unmet medical needs in diabetes, oncology, immunology, and neuroscience. We are looking for a highly skilled Scientific Director to join our Biotherapeutic Lead Optimization team. The ideal candidate will have extensive experience in biotherapeutic design, engineering, and modalities including mAbs, bsAbs, proteins, small molecules, oligonucleotides, and peptide bioconjugates. This role requires a thorough understanding of large molecule drug discovery and disease biology. Are you eager to drive innovation in a collaborative environment? Join us to make a difference.
Responsibilities:

• Lead biotherapeutic design and engineering projects from concept to clinical development.
  
• Oversee development of mAbs, bsAbs, proteins, and bioconjugates, ensuring innovative approaches.
  
• Collaborate with cross-functional teams in drug discovery and development.
  
• Provide scientific expertise to influence project and portfolio strategies.
  
• Mentor and develop junior scientists to foster team growth.
  
• Stay updated on emerging trends and technologies in biologics.
  
• Represent Lilly at scientific conferences and establish external collaborations.
  
  Basic Requirements:
  
  
• PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 7+ years in biotherapeutics R&D.
  
• Proven track record in lead discovery and optimization for various biologics formats.
  
• Successful delivery of clinical candidates across therapeutic areas.
  
• Deep understanding of large molecule drug discovery and development processes.
  
• Expertise in protein design, structure-function relationships, and developability assessments.
  
• Supervisory and talent management experience.
  
  Additional Skills/Preferences:
  
  
• Experience collaborating with computational and discovery groups.
  
• Experience with automation and high-throughput workflows.
  
• Familiarity with protein structure analysis tools (Pymol, Chimera, MOE).
  
• Strong communication skills.
  
• Excellent organizational skills and adaptability.
  
• Ability to navigate complex organizational issues effectively.
  
  Additional Information:
  

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• Location: Indianapolis, Indiana
  
• Travel: 0-10%
  
  Lilly is committed to workforce inclusion for individuals with disabilities. If accommodations are needed to apply, please complete the . Lilly is an EEO employer, valuing diversity and equal opportunity.
  Our employee resource groups (ERGs) support diverse communities and are open to all employees. Current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network, Lilly India Network, Organization of Latinx at Lilly, PRIDE, Veterans Leadership Network, Women's Initiative for Leading at Lilly, enAble, and others.
  Compensation for this role ranges from $144,000 to $250,800, depending on experience, education, and location. Employees are eligible for bonuses, comprehensive benefits, 401(k), pension, and other perks. Lilly reserves the right to modify these programs at its discretion.
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